Abboud N, Chow SK, Saylor C, Janda, A, Ravetch, J V, Scharff, M D, and Casadevall, A. 2010. A requirement for FcgammaR in antibody-mediated bacterial toxin neutralization. J Exp Med 207:2395-405.

Rivera J, Cordero RJ, Nakouzi AS, Frases S, Nicola A, and Casadevall A. 2010. Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins. Proc Natl Acad Sci U S A  107:19002-7

Varshney AK, Martinez LR, Hamilton SM, Bryant, A E, Levi, MH, Gialanella, P, Stevens, DL, and Fries, BC. 2010 Augmented production of Panton-Valentine leukocidin toxin in methicillin-resistant and methicillin-susceptible Staphylococcus aureus is associated with worse outcome in a murine skin infection model. J Infect Dis 201:92-6.

Vaccines

Chattopahyay A and Rose JK. 2011. Complementing defective viruses that express separate paramyxovirus glycoproteins provide a new vaccine vector approach. J Virol 85:2004-11.

Schwartz JA, Buonocore L, Suguitan AL, Jr. Silaghi, A, Kobasa, D, Kobinger, G, Feldmann, H, Subbarao, K, and Rose JK. 2010 Potent vesicular stomatitis virus-based avian influenza vaccines provide long-term sterilizing immunity against heterologous challenge. J Virol 84:4611-8.

Wang TT, Tan GS, Hai R, Pica N, Petersen E, Moran TM, and Palese P. 2010. Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins. PLoS Pathog 6:e1000796.

Diagnostics and Pathogen Discovery

Palacios G, Tesh R, Travassos da Rosa A, Savji N, Sze W, Jain K, Serge R, Guzman H, Guevara C, Nunes MR, Nunes-Neto JP, Kochel T, Hutchison S, Vasconcelos PF, and Lipkin WI. 2011. Characterization of the Candiru antigenic complex (Bunyaviridae: Phlebovirus), a highly diverse and reassorting group of viruses affecting humans in tropical America. J Virol epub Feb 2.

Epstein JH, Quan PL, Briese T, Street, C, Jabado, O, Conlan, S, Ali Khan, S, Verdugo, D, Hossain, M J, Hutchison, S.K, Egholm, M, Luby, S P, Daszak, P, and Lipkin, W. I. 2010. Identification of GBV-D, a novel GB-like flavivirus from old world frugivorous bats (Pteropus giganteus) in Bangladesh. PLoS Pathog 6:e1000972.

Quan PL, Wagner TA, Briese T, Torgerson TR, Hornig M, Tashukhamedova A, Firth C, Palacios G, Baisre-De Leon A, Paddock CD, Hutchison SK, Egholm M, Zaki SR, Goldman JE, Ochs HD, and Lipkin WI. 2010. Astrovirus encephalitis in boy with X-linked agammaglobulinemia. Emerg Infect Dis16:918-25.

Therapeutics

Liao M, Sanchez-San Martin C, Zheng A, and Kielian M. 2010. In vitro reconstitution reveals key intermediate states of trimer formation by the dengue virus membrane fusion protein. J Virol 84:5730-40.

Porotto M, Rockx B, Yokoyama CC, Talekar, A, Devito, I, Palermo, L M, Liu, J, Cortese, R, Lu, M, Feldmann, H, Pessi, A, and Moscona, A. 2010. Inhibition of Nipah virus infection in vivo: targeting an early stage of paramyxovirus fusion activation during viral entry. PLoS Pathog 6:e1001168.

Porotto M, Yokoyama CC, Palermo LM, Mungall, B, Aljofan, M, Cortese, R, Pessi, A, and Moscona, A. 2010. Viral entry inhibitors targeted to the membrane site of action. J Virol 84:6760-8.

Innate Immunity

Laurent-Rolle M, Boer EF, Lubick KJ, Wolfinbarger, J B, Carmody, A B, Rockx, B, Liu, W, Ashour, J, Shupert, W L, Holbrook, MR, Barrett, A D, Mason, PW, Bloom, M E, Garcia-Sastre, A, Khromykh, A A, and Best, S M. 2010. The NS5 protein of the virulent West Nile virus NY99 strain is a potent antagonist of type I interferon-mediated JAK-STAT signaling. J Virol 84:3503-15.

Prins KC, Delpeut S, Leung DW, Reynard, O, Volchkova, VA, Reid, S P, Ramanan, P, Cardenas, W B, Amarasinghe, G K, Volchkov, VE, and Basler, C. F. 2010. Mutations abrogating VP35 interaction with double-stranded RNA render Ebola virus avirulent in guinea pigs. J Virol 84:3004-15

Tscherne DM, Manicassamy B, and Garcia-Sastre A. 2010. An enzymatic virus-like particle assay for sensitive detection of virus entry. J Virol Methods 163:336-43.

Microbial Pathogenesis

Luhrmann A, Nogueira CV, Carey KL, and Roy CR. 2010. Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein. Proc Natl Acad Sci U S A 107:18997-9001.

Pan X, Luhrmann A, Satoh A, Laskowski-Arce MA, and Roy CR. 2008. Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Science 320:1651-4.

Runco LM, Myrczek S, Bliska JB, and Thanassi DG. 2008. Biogenesis of the fraction 1 capsule and analysis of the ultrastructure of Yersinia pestis. J Bacteriol 190:3381-5.

Developmental Projects

Yi Z, Sperzel L, Nurnberger C, Bredenbeek PJ, Lubick KJ, Best SM, Stoyanov CT, Law LM, Yuan Z, Rice CM, and MacDonald MR. 2011. Identification and characterization of the host protein DNAJC14 as a broadly active flavivirus replication modulator PLoS Pathog 7:e1001255

Bublitz DC, Noah CE, Benach J, and Furie MB. 2010. Francisella tularensis suppresses the proinflammatory response of endothelial cells via the endothelial protein C receptor. J Immunol 185:1124-31.

Kim JN, Blount KF, Puskarz I, Lim J, Link KH, and Breaker RR. 2009. Design and antimicrobial action of purine analogues that bind Guanine riboswitches. ACS Chem Biol 4:915-27.

New Opportunities

Gavrilovskaya IN, Gorbunova EE, and Mackow ER. 2010. Pathogenic hantaviruses direct the adherence of quiescent platelets to infected endothelial cells. J Virol 84:4832-9.

Matthys VS, Gorbunova EE, Gavrilovskaya IN, and Mackow ER. 2010. Andes virus recognition of human and Syrian hamster beta3 integrins is determined by an L33P substitution in the PSI domain. J Virol 84:352-60.

Novikova M, Kazakov T, Vondenhoff GH, Semenova E, Rozenski J, Metlytskaya A, Zukher I, Tikhonov A, Van Aerschot A, and Severinov K. 2010. MccE provides resistance to protein synthesis inhibitor microcin C by acetylating the processed form of the antibiotic. J Biol Chem 285:12662-9.

Career Development

Lara-Tejero M, Kato J, Wagner S, Liu X, and Galan JE. 2011. A sorting platform determines the order of protein secretion in bacterial Type III Systems. Science epub Feb 3.

Steel J, Palese P, and Lowen AC. 2010. Transmission of a 2009 pandemic influenza virus shows a sensitivity to temperature and humidity similar to that of an H3N2 seasonal strain. J Virol 85:1400-2.

Wang P, Arjona A, Zhang Y, Sultana H, Dai J, Yang L, LeBlanc PM, Doiron K, Saleh M and Fikrig E. 2010. Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Nat Immunol 11:912-9.